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Several studies using islets and insulinoma cell lines have clearly demonstrated that GSIS elevates the level of several intermediates of the TCA cycle and promotes the export of some of them from mitochondria to the cytoplasm

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doi: 10.1016/j.neuint.2020.104772 20 QuddosFHubshmanZTeggeASaneDMartiEKablingerASet al

Discussion Following systemic administration, the biological processes that nanoparticles undergo, conditioned by their physicochemical properties, affect their fate in the body, making the targeting to specific organs challenging

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