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When combined with caloric restriction: the same study's diet-plus-injection arm showed 3.2 kg (7 pounds) additional loss versus diet-plus-placebo at 12 weeks, which was statistically significant (p=0.03)

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According to a 2019 study led by Harvard T.H

GLP-1 injectable medications require temperature-controlled shipping to maintain potency

Journal of the American Chemical Society, 85 (14), 21492154