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However, 3-KO mice failed to show any significant changes in body weight following treatment with AOD9604 or hGH

A higher Pgp activity during the night period also may have contributed to the differences between morning and night Tac administrations observed

You can no longer be certain that the effects (or lack thereof) are due to the peptide itself

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However, benefits often outweigh risks in eligible patients, and side effects commonly improve with dose titration and time