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Cell Physiol Biochem: Int J Exp Cell Physiol Biochem Pharmacol

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Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]

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Research also documents myostatin inhibition in these models myostatin ordinarily functions as a natural limiter on muscle tissue growth, so suppressing its activity is one mechanism researchers point to when explaining anabolic signaling outcomes in study data

Key accelerators include: Mitochondrial dysfunction: Leading to reduced energy output and increased reactive oxygen species (ROS)