Immune regulation balancing inflammatory responses
297 In vitro experiments have found that oligomeric A increases PGC-1 and SIRT1 levels, disrupting their interaction, which is crucial for maintaining metabolic balance
At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta
FIGURE 8 FIGURE 9 Conclusion By using the GPX4 activator compound as chemical probe, we demonstrated that up-regulation of GPX4 activity can reduce the production of inflammatory agents and promote inflammation resolution ( Figure 10 )
Cell Death Dis 10(11):822 Chen X et al (2021) Cellular degradation systems in ferroptosis
Promising therapeutic strategies include natural inhibitors (e.g., baicalin, silymarin, quercetin), pharmacological inhibitors like chlormethiazole, and gene-targeting approaches such as clustered regularly interspaced short palindromic repeat (CRISPR)-associated nuclease 9 (Cas9)-mediated knockdown in preclinical models [107, 110112]
