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Antioxid Redox Signal (2012) 17(1):110

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This suggests that clopidogrel may be harmful in patients with diabetes and CKD.118 Similarly, in stroke prevention guidelines among patients with a recent non-cardioembolic stroke/transient ischemic attack, the dual antiplatelet therapy strategy with aspirin and clopidogrel is recommended for 21 days, while dual antiplatelet therapy for longer than three months is discouraged.105,106,119 In The Acute Stroke or Transient Ischemic Attack Treated with Ticagrelor and ASA for Prevention of Stroke and Death (THALES trial) among patients with a mild-to-moderate acute non-cardioembolic ischemic stroke or transient ischemic attack who were not undergoing intravenous or endovascular thrombolysis, the risk of the composite of stroke or death within 30 days was lower with ticagreloraspirin than with aspirin alone, however there were no differences in incidence of disability between the two groups and severe bleeding was more frequent with ticagrelor