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Received: 22 June 2019 Accepted: 19 August 2019 Published: 28 November 2019 Glutathione (GSH), a compound derived of a combination of three amino acids - cysteine, glycine and glutamine - is the final product of homocysteine (Hcy) metabolism in the transsulfuration pathway

Iron overload promotes the polarization of M1 macrophages by increasing the levels of M1 markers interleukin-6, tumour necrosis factor, and interleukin-1 and decreasing the levels of M2 marker tissue transglutaminase-2 [81]

71 ROS can also activate downstream effectors like PKC 72 and JNK, 73 which are independently associated with DPN pathology

10.1517/17425255.4.1.93PubMed Abstract | CrossRef Full Text | Google Scholar 59 HsiehY.KorfmacherW