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In depression, the inflammatory phenotype is particularly associated with atypical symptoms, including increased sleep and appetite, potentially leading to weight gain and local inflammation and macrophage infiltration in the adipose tissue, creating a self-perpetuating inflammatory loop [81]

Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

Rev Med Interne 2008;29:187-94

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(PubMed) Tesfaye S, Selvarajah D

Pfizer also said that the placebo-adjusted reduction in mean body weight had ranged from -5% to -9.5% at 26 weeks and -8% to -13% at 32 weeks