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That cross-substance signal points to a shared biology underlying addiction, and it opens the door to a fundamentally different approach: not treating one addiction at a time, but targeting that common biologic signal, that common craving across addictions."

the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor

T2DM is a major risk factor for the development of cardiovascular disease

It can improve joint function and mobility without the side effects often associated with NSAIDs

BMC Cardiovasc Disord, 2014, 14, 88

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite