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Although the enrichment of L-cells by pharmacological agents can be a novel approach for improving insulin secretion, glucose tolerance and the treatment of T2DM, more research for the specific differentiation of L-cells and the translation of in vitro and animal data to humans, are needed for the success of this approach

The activated Akt subsequently modulates many downstream effector proteins associated in cell survival, proliferation, metabolism, and glucose transport (Fletcher et al

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The assay has been validated with both GLP-1 (7-36), the endogenous physiological full agonist secreted by intestinal L-cells, and its metabolite GLP1 (9-36) which is a weaker partial agonist