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In addition, androgen overload, lipid deposition, inflammatory cytokines, and other systemic factors are also involved in the IR process of peripheral tissues [53] (Fig

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Microglia and astrocytes start to release proinflammatory cytokines into the extracellular space

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Nausea, diarrhea, vomiting, constipation, abdominal pain, decreased appetite, and fatigue occurring in 5% of participants in clinical trials, mostly mild-to-moderate and peaking during dose escalation

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