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It states plainly that semaglutide is not approved specifically for inflammation or autoimmune conditions, and that people with active autoimmune disease, thyroid dysfunction, or inflammatory bowel disease should discuss its use carefully with a provider because GLP-1 effects in these populations remain understudied

The first-line standard drug used in RA is MTX and about 40% of the RA patients are sensitive to it (Peres et al

N = 8/group