For some patients, this blood pressure reduction eliminates the need for an additional antihypertensive medication
When GLP-1RAs act on the gastrointestinal tract, they could extend the gastric emptying time
An exploratory analysis of genetic data of patients from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial showed that different haplotypes encoding for GLP-1R correlated with variable response rates to antipsychotic medications 132
These findings underscore a robust and consistent CV benefit across longer-acting GLP-1RAs
Tirzepatide has received approval for use in patients with T2D following several phase 3 studies testing and demonstrating its marked anti-hyperglycemic efficacy and positive actions on multiple cardiovascular risk factors, associated with an excellent safety profile [2, 3]
What varies is provider type (physician versus NP or PA), pharmacy partner, and subscription tier