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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

The lack of central carbon and nitrogen catabolism not only leads to energy deficiency but also reduces the supply of the main metabolite anabolic precursors such as pyruvate, acetyl-CoA, glucose-6-phosphate, and erythrose 4-phosphate used for biomass biosynthesis 21

CAMP participants were considered typically developing (TYP) if the MSEL DQ was greater than 70 and the participant did not receive a diagnosis of developmental delay or autism

doi: 10.4049/jimmunol.174.6.3137