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On a mechanistic level, licochalcone A has an anti-inflammatory effect by modulating pro-inflammatory mediators, and decanediol exhibits antibacterial activity targeting Cutibacterium acnes

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The aminobenzyl alcohol motif is the classical choice for this role Several derivatives have since been developed to fine-tune performance, including: Differently substituted aminobenzyl alcohols Extended benzyl alcohol variants Heteroaryl-linked spacers These structural modifications allow chemists to optimize: Payload release kinetics Aqueous solubility Overall linker stability Opportunities for ADC Development This structural diversity provides researchers with the flexibility to tailor -glucuronidase-cleavable linkers to specific therapeutic goals, while retaining the robust enzymatic trigger that ensures reliable release

These findings suggest the involvement of ROS in neurodegenerative diseases [4, 8, 9]