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The FLOW trial demonstrated clear kidney and cardiovascular protection with GLP-1 receptor agonist (GLP-1RA) treatment in individuals with type 2 diabetes and chronic kidney disease (CKD)

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Age-related deterioration of the central SCN clock has been demonstrated in animal models at molecular and electrophysiological levels (e.g., reduced amplitude of SCN clock gene expression and firing) and likely underlies some of these changes

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