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Dihexa binds to the HGF receptor c-Met with high affinity, and once bound, it triggers intracellular signaling cascades (primarily PI3K/Akt and MAPK/ERK pathways) that remain active for hours beyond peptide clearance

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At the centennial of Michaelis and Menten, competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose

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