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Its crucial to adhere to recommended cycle lengths (e.g., 30-60 days on, followed by an equal period off) to prevent this and maintain efficacy

doi:10.1016/0003-2697(79)90720-6

However, the vital question is Do they have the same effect

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[3] These studies also suggest that DSIP could attenuate the excitatory actions of NMDA receptors, further contributing to its sleep-promoting properties

If you are using exfoliating acids or retinoids, it is highly recommended to introduce them gradually or alternate their use to avoid irritation