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Studies in other systems have directly shown that iron accumulation can drive senescence and the expression of SASP factors [112]

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Glutathione is useful during the transition, but if you're still dependent on it six months into treatment, something upstream isn't improving the way it should

WuKYuanYYuHDaiXWangSSunZet alThe gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

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Understanding which neurotransmitter system is primarily affected can help guide treatment decisions, something we will explore in the strategies section below