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A 2026 review in Anais Brasileiros de Dermatologia found most local reactions are transient and resolve without dose adjustment

neurodegenerative diseases, such as Alzheimer's or Parkinson's

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While the most common underlying comorbidities are reported to be obesity, hypertension, diabetes, underlying cardiovascular and lung disease, people with immune-mediated diseases such as autoimmune disease, and those on immune-suppresants or immune-modulating drugs may also be more vulnerable to this infection

While GHK-Cu cannot eliminate external stressors, its anti-inflammatory properties may partially buffer stress effects on follicular health