In healthy individuals, CBF is tightly coupled to the metabolic demands of neurons (Claassen et al., 2021), however, it is unclear whether reduced CBF in ADRD is a cause or consequence of cerebral hypometabolism
T4 was shown to form a functional complex with PINCH and integrin-linked kinase (ILK), activating the survival kinase Akt
Certain medical conditions, such as kidney problems or certain allergies, may require caution or adjustments in the treatment plan
Fedosov SN, Brito A, Miller JW, Green R, Allen LH
*Correspondence: Luhua Lai, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
These comprise drug nanoparticles embedded in a stabilizing matrix, enhancing solubility and enabling controlled drug release