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High-fat diets have been shown to exacerbate insulin resistance and impair glucose oxidation, while caloric restriction and ketogenic diets have been associated with improved metabolic flexibility and reduced reliance on lipid metabolism (44)

Individuals with difficult vein access or bleeding disorders may also be at higher risk for complications, such as bruising or infection at the injection site

Collectively, these studies underscore the essential significance of epigenetic modifications in relation to cellular aging and DN

Gao F, Koenitzer JR, Tobolewski JM, et al

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