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In summary, the action of valproate in neural systems is complex, with one aspect including downregulation of PKC signaling, which overlaps with symptom amelioration of manic states in animal models, suggesting that modulation of PKC overactivity is a mechanism that is favored by valproate

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Piotrowska A, Chmielewska M, Andrzejewski W et al (2020) Influence of angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies

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Qu S, Qin T, Li M, Zhang S, Ye L, Wei J, et al

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