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These results were observed after intermittent treatment over several weeks

GHK-Cu downregulates acute-phase and pro-inflammatory cytokines (TNF-?, IL-6), upregulates anti-oxidant defenses (including superoxide dismutase, Nrf2 and HO-1 pathways), and suppresses fibrotic signaling by inhibiting TGF-?1/Smad2/3 activation

The enzyme was relatively stable over a pH range of 7.48.9, but it lost 93% of the original activity if the pH was raised to 9.8

Topical application is effective for surface skin remodeling but does not replicate the systemic signaling that injectable protocols produce

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