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cross-trial comparisons are not appropriate given differences in study design, populations, and timepoints, and no superiority claims can be made on this basis

or overweight if their BMI is greater than 27 accompanied by weight-related medical problems such as high blood pressure, type 2 diabetes, or high cholesterol

Managing this alternating pattern requires a balanced approach

ZSP1601 is a first-in-class pan-phosphodiesterase (pan-PDE) inhibitor specially designed for MASH by Guangdong Raynovent Biotech Co., Ltd (Guangdong, Guangzhou, China)

Retatrutide is now drawing attention because it adds another receptor target into the conversation

Dr Kath McCullough, special adviser on obesity at the Royal College of Physicians, described the results as encouraging and said treatments such as retatrutide could be life-changing for many people living with obesity and diabetes