There's no medicine like that, Al-Aly said
This suggests the medication continues working beyond one year without plateau
GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied
As food passes through your stomach, the beneficial bacteria that live in your gut (like Akkermansia and Clostridium butyricum) convert the fiber into butyrate and Akkermansia secretes a protein called P9
But energy deficits come with trade-offs, including fatigue, reduced exercise capacity, slower recovery, and in some cases, loss of lean muscle tissue
However, making very important lifestyle changes like eating a healthy diet and getting more physically active often are not enough to prevent regaining weight