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doi: 10.1016/j.intimp.2019.105969 28 HelmstdterJKeppelerKAustFKsterLFrenisKFilippouKet al

Independent 12-week clinical study (33 patients, ages 4065): 94% saw brighter skin | 85% saw more even tone | 91% felt skin more hydrated & dewy

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Targeting at lipogenesis, pyruvate carboxylase is proven to activate AKT/mTOR pathway, thus upregulating SREBP1c and FASN-induced lipogenesis in TC cells, which promotes anticancer effects [128]