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This leads to a reduction in ATP production and, therefore, an increase in the level of AMP and as a result activation of AMPK

Nature 437 , 12791285 (2005)

(60) utilized next generation sequencing (NGS) and computational analysis to demonstrate that miR-23b-3p, acting as a tumor suppressor, can inhibit tumor Gln metabolism by targeting GLS1, thereby enhancing the sensitivity of liver tumor cells to sorafenib