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In atopic dermatitis mouse models, AES16-2M administration downregulated disease scores, ear thickness, serum IgE (a key marker of allergic disease), and TSLP

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Because of its slow release properties, fewer injections may be required compared to other B12 forms such as cyanocobalamin

This distinction is vital for researchers who need to maintain a pristine chemical environment over several weeks of testing

however, evidence from animal [134, 135] and cellular studies [136,137,138] has demonstrated that chronic IH is more likely to cause ECD than chronic persistent hypoxia