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Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, uncontrolled hypertension, and certain kidney conditions

You don't need to take massive doses

Sadhu SS, Xie J, Zhang H, Perumal O, Guan X

doi:10.4103/2045-9912.229599 120 De Flora, S., Grassi, C

For example: Semaglutide (Wegovy) : Patients lost an average of 15% of their body weight over 68 weeks