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Hypothyroidism slows metabolism regardless of reduced food intake, PCOS creates insulin resistance that makes fat loss harder, and chronic stress elevates cortisol in ways that signal your body to hold onto weight

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doi: 10.1016/j.cden.2013.12.009

This rapid absorption and clearance profile aligns with its physiological role as a mealtime hormone pramlintide is administered immediately before each major meal to replicate the prandial amylin release that is deficient in insulin-treated diabetes

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