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Frontiers in Pharmacology, 2022

Winston, J

In contrast, DPP-4 inhibitors exert a natriuretic effect by acting primarily on distal segments, apparently by enhancing the effects of SDF-1 [99] (Fig

This suggests that DSIP does not activate all mitochondrial respiration but specifically enhances ATP synthesis [2]

Previous studies indicate that IGF-I is a potent vasodilator[152], and that this effect may be partly mediated by increased NO release from the endothelium[153, 154]