The impact of reducing gastric pH with omeprazole on the PK of oral semaglutide has been assessed and this may cause a small but not clinically relevant increase in semaglutide exposure [19]
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In the setting of gut-derived neuroinflammation, ISR activation robustly promoted transcription of LD biogenesis genes, leading to excessive neutral-lipid accumulation in microglia, whereas pharmacological ISR blockade (with ISRIB) largely reversed the LD burden evoked by inflammatory stimuli, confirming the causal role of ISR in lipotoxic injury
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