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UC Davis exercise physiologist Keith Baar, speaking in late 2025, put it plainly: "It is still important for patients taking GLP-1 medication to limit muscle wasting through exercise and high-quality protein." The American College of Sports Medicine and major endocrinology bodies now recommend that GLP-1 users prioritize: Resistance training with multijoint movements - exercises that load multiple muscle groups simultaneously and create high mechanical tension, particularly in the posterior chain (glutes, hamstrings, lower back) Progressive overload - progressively increasing the demand on the muscles over time to continue signaling retention and growth Consistent training frequency - 3 to 5 sessions per week to maintain the anabolic signal during prolonged caloric restriction Adequate protein intake - 1.2 to 2.0 grams per kilogram of body weight daily, timed around training sessions The challenge for most GLP-1 users is practical: they're often new to structured training, may have limited mobility or joint issues related to their previous weight, and don't want to split their routine across a separate cardio machine and a weights area

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