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12.5 mg and 15 mg (maximum doses): At these levels, the side effect profile is well-established for each individual

Follow appropriate laboratory handling procedures after reconstitution

Rotating injection sites with each dose helps minimise these effects and ensures optimal medication absorption

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The decision to terminate the clinical trial early was based on the recommendation of independent Data Monitoring Committee (DMC), which concluded that the results from an interim analysis met certain pre-specified criteria for stopping the trial early for efficacy [2]

Screening includes serum B12, RBC thiamine, and PLP (B6) tests, plus homocysteine and MMA levels