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However, critical barriers hinder their clinical translation: (1) regulatory and scalability challenges, such as standardizing sterilization/long-term stability for liposomes/SLNs, require rigorous evaluation of immune responses (e.g., PEGylated liposomal uricase) and cost-effectiveness for advanced systems (biomimetic nanoliposomes and ethosomal gels)

Possible heterogeneity of glial senescence As discussed, cellular senescence is a stable form of cell cycle arrest triggered by stress, aging, or oncogene activation

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These include: Redness, itching, pain, rashes, and sensitivity at the site of injection Dry mouth Nausea Headaches Lightheadedness Fever (that is transient, and goes away quickly) Some of these side effects are easily avoided or treated