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Data published to date including results from a Phase 2 trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) provide early insights into its gastrointestinal tolerability profile

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Withdrawal Symptoms: When individuals stop using acetaminophen-opioid drugs, they experience withdrawal symptoms such as nausea, sweating, muscle pain, and anxiety

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Limit High-Purine Foods : Purines are substances found in certain foods that the body breaks down into uric acid