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However, while severe instances of ariboflavinosis are rare in those countries, a significant portion of the population experiences a subclinical deficiency phase, characterised by changes in biochemical markers, as can be detected by analysing vitamin levels in bodily fluids, such as blood plasma, urine, and serum [39]

Future trials should adopt: Adaptive designs : allow protocol adjustments based on interim data

The protein backbone is shown as a semi-transparent magenta ribbon

5.1 Responses to abiotic stress Abiotic stress refers to non-biological environmental factorsincluding drought, extreme temperatures, soil salinity, flooding, soil acidity (low pH), nutritional deficiencies, heavy metal toxicity, and ultraviolet radiationthat limit plant growth, survival, or reproduction (Lull et al., 2008

Heuer M, Aust G, Ode-Hakim S, Scherbaum WA

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