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For instance, the degradation products of high-molecular-weight hyaluronic acid activate TLR2/4 and cluster of differentiation 44 (CD44), thereby promoting the inflammatory process in obesity and rheumatoid arthritis (RA) [12]

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Specifically, the researchers observed a 15% reduction in the risk of developing nonexudative AMD and a 20% decrease in the incidence of exudative AMD compared to those receiving alternative diabetes therapies

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JAMA J Am Med Assoc

Clinical judgement should be used in these cases, recognising that there may be elevated clinical risk for patients where medicines are not assessed by the TGA for safety, quality, and efficacy