It doesnt impair function
Topiramate does not affect cardiovascular parameters but requires attention to hydration and kidney stone prevention
Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise (Huang et al., 2024), suggesting that future therapies could be tailored to preserve metabolic benefits while minimizing gastrointestinal side effects
376 GLP-1RAs in Enhancing Exercise Endurance Studies indicate that acute exercise and short-term endurance training significantly increase GLP-1 secretion in mice
Liraglutide therapy exhibited good safety tolerability, with gastrointestinal symptoms representing the predominant adverse events: nausea affected 46% of liraglutide users vs
The presence of obesity-related complications such as obstructive sleep apnea, metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), or cardiovascular disease may justify longer treatment duration given the health benefits of sustained weight loss
