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The increase in Lac-Phe production induced by metformin is directly related to the inhibition of complex I of the oxidative phosphorylation machinery

Moreover, COX-2 inhibitors can cause metabolic imbalances that result in over production of two toxic cytokines, tumor necrosis factor alpha (TNF-) and interleukin 1 beta (IL-1) (Takahashi 1998

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The basis for anticancer properties of green tea polyphenols in vitro and in vivo could due to their antioxidant or pro-oxidant properties (Fig 2)

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There are studies using intravenous (IV) glutathione that demonstrate its ability to improve Parkinsons symptoms