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10.1016/j.conb.2009.05.001 3

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We saw this effect specifically in people taking the medications that actually target that receptor. Together, these findings underscore a central principle of pharmacogenetics: genetic variation can shape not only whether a drug works, but also how it is experienced, often in highly drug-specific ways

Melanotan II is a non-selective pan-melanocortin agonist (MC1R+MC3R+MC4R+MC5R), whereas PT-141 (Bremelanotide) is more selective for MC3R/MC4R with minimal MC1R activity

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