In clinical trials, participants who took the highest dose of the once-daily pill achieved an average weight loss of 12.4 percent, or 27.3 pounds, after 72 weeks, compared with 2.2 pounds with the placebo
Speak to a healthcare professional
I use relatively low doses
Lastly, if a patient is already experiencing damage to his or her eyes due to high blood sugar (called diabetic retinopathy), one should consult with their eye doctor before starting a GLP-1, especially semaglutide
A fair comparison would require mazdutide to be tested against semaglutide 2.4 mg, which has not happened yet
There is also a more subtle risk worth knowing: the Pasqua 2025 trial reported two cases of euglycemic ketosis without acidosis in semaglutide-treated participants