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This evolution reflects a growing understanding of the gut-brain-liver axis and the complex neuroendocrine regulation of energy balance

Acknowledgments The authors would like to acknowledge Ms

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Educational background: Semaglutide as a molecule was originally developed for type 2 diabetes by Novo Nordisk and is sold under the brand names Ozempic (for diabetes) and Wegovy (for chronic weight management, introduced for weight management in 2021)