Ghrelin is also involved in glucose homeostasis, as it inhibits insulin secretion and modulates insulin sensitivity, ultimately leading to increased blood glucose levels 80,81
But it doesnt automatically make semaglutide a pain drug. Weight reduction can relieve joint pain, and metabolic improvements may dampen inflammation
Acta 1830 , 31653172 (2013)
40 juvenile male Western Albino rats (aged 34Ramaekers et al., weeks) received oral PPA at 250 mg/kg/for 3 days to induce autism-like features, followed by 3 weeks of probiotic treatment with Bifidobacterium infantis , Lactobacillus bulgaricus, or a commercial probiotic mixture (all at 0.2 g/kg)
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial
This post is focused specifically on the decision itself