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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

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This group includes phenytoin and diazepam

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It might appear that a set of antioxidant assays based on oxidants/indicators of different redox potentials could provide information on the contribution of antioxidants with various redox potentials to TAC, thereby making the analysis of TAC more insightful