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Fller M, Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, et al

Higginson M

10.1038/ng.3680 Nat Genet

It dissolves more poorly in water the colder the water is, and its susceptible to significant degradation depending on the temperature and pH of its solution and the time it spends there.17 Other forms of creatine have come out that try to account for this, including buffered forms that alter its pH to make it dissolve more thoroughly in cold water