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Side Effects and Tolerability Common side effects may include nausea, diarrhea, and constipation, particularly when starting the medication
Safety and unknowns GLP-1 drugs are strong medicines: Common side effects: nausea, vomiting, diarrhoea, constipation Possible nutrition issues if eating becomes very limited Limited data around implantation and very early pregnancy
The SELECT trial (N=17,604) demonstrated that semaglutide 2.4 mg reduced the composite endpoint of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke by 20% in adults with established cardiovascular disease and overweight or obesity, independent of diabetes status (HR 0.80
Retatrutide fatigue in people who exercise regularly Active individuals notice fatigue more acutely because they have higher energy demands
SAR425899 (Sanofi) is another example of a GLP-1/glucagon co-agonist which has been tested in Phase 1 trials
