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The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis

Several studies have demonstrated that women with PCOS who use GLP-1 receptor agonists experience greater improvements in menstrual regularity and ovulation rates compared to those relying on lifestyle changes alone

Therefore, it is recommended to reduce processed food intake and adopt healthier dietary patterns to mitigate these effects [38, 40]

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