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SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride

Together, these factors form an integrated molecular network in which NO-mediated perfusion facilitates nutrient delivery, leucine-driven mTOR activation supports muscle anabolism, and exercise-induced AMPK signaling maintains metabolic efficiencycollectively counteracting the anabolic resistance associated with aging

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Nature 477 , 9094 (2011)

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